(dollars in thousands)

Year Ended December 31
2011
2010
2009
Cash Flow From (Used in) Operating Activities:
     
Net earnings
$4,728,449
$4,626,172
$5,745,838
Adjustments to reconcile earnings to net cash from operating activities — Depreciation
1,395,371
1,207,450
1,210,977
Amortization of intangible assets
1,648,523
1,416,855
878,533
Derecognition of a contingent liability associated with the conclusion of the TAP Pharmaceutical Products Inc. joint venture
(797,130)
Share-based compensation
382,602
387,183
366,357
Acquired in-process and collaborations research and development
672,500
313,200
170,000
Investing and financing (gains) losses, net
141,565
126,337
41,967
Trade receivables
(670,152)
(394,665)
(387,749)
Inventories
(129,621)
139,857
230,555
Prepaid expenses and other assets
413,266
553,145
(386,889)
Trade accounts payable and other liabilities
1,789,652
572,533
(374,715)
Income taxes
(1,402,078)
(212,086)
577,416
Net Cash From Operating Activities
8,970,077
8,735,981
7,275,160
Cash Flow From (Used in) Investing Activities:
     
Acquisitions of businesses and technologies, net of cash acquired
(672,500)
(9,433,243)
(2,370,630)
Acquisitions of property and equipment
(1,491,500)
(1,015,075)
(1,089,048)
Purchases of investment securities
(5,109,987)
(805,932)
(248,970)
Proceeds from sales of investment securities
5,648,720
954,361
16,306
Release of (deposit of) restricted funds
1,870,000
(1,870,000)
Other
16,099
(18,426)
(6,368)
Net Cash From (Used in) Investing Activities
260,832
(12,188,315)
(3,698,710)
Cash Flow From (Used in) Financing Activities:
     
(Repayments of) proceeds from issuance of short-term debt and other
(1,964,685)
(203,854)
3,217,331
Proceeds from issuance of long-term debt and debt with maturities over 3 months
1,000,000
4,000,000
3,000,000
Repayments of long-term debt and debt with maturities over 3 months
(3,012,426)
(1,673,998)
(2,483,176)
Purchases of common shares
(77,007)
(866,825)
(826,345)
Proceeds from stock options exercised, including income tax benefit
968,759
328,411
508,669
Dividends paid
(2,938,096)
(2,671,475)
(2,414,460)
Net Cash (Used in) From Financing Activities
(6,023,455)
(1,087,741)
1,002,019
Effect of exchange rate changes on cash and cash equivalents
(43,005)
(620,893)
118,848
Net Increase (Decrease) in Cash and Cash Equivalents
3,164,449
(5,160,968)
4,697,317
Cash and Cash Equivalents, Beginning of Year
3,648,371
8,809,339
4,112,022
Cash and Cash Equivalents, End of Year
$6,812,820
$3,648,371
$8,809,339
Supplemental Cash Flow Information:
     
Income taxes paid
$1,781,602
$809,710
$635,445
Interest paid
544,559
580,168
514,326

The accompanying notes to consolidated financial statements are an integral part of this statement.

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